Linked Life Data

7744296

Source:http://linkedlifedata.com/resource/pubmed/id/7744296

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-6-12
pubmed:abstractText
Dietary restriction was used in this study as a modulator of free radical reactions to examine the effects of age on the physico-biochemical property of synaptosomal membranes. Synaptosomal membranes were isolated from the frontal cortices of 6- and 24-month-old barrier-reared male Fischer 344 rats maintained on either an ad lib (AL) or a 40% diet restricted (DR) feeding schedule. The age-related production of reactive oxygen species (ROS) was only seen in the AL group, and dietary restriction suppressed the amount of the reactive species at both ages. Although membrane fluidity significantly decreased with age in AL fed rats, no change occurred in DR rats. Because age-related increases in cholesterol/phospholipid occurred in both AL and DR groups, fluidity loss may be influenced by factors other than cholesterol. We suggest that lipid peroxidation may be a major factor in the change in fluidity during the aging process.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0891-5849
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Brain synaptosomal aging: free radicals and membrane fluidity.
pubmed:affiliation
University of Texas Health Science Center at San Antonio, Department of Physiology 78284-7756, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't