Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1995-6-14
pubmed:databankReference
pubmed:abstractText
Cardiac myosin binding protein-C (cardiac MyBP-C, cardiac C protein) belongs to a family of proteins implicated in both regulatory and structural functions of striated muscle. For the cardiac isoform, regulatory phosphorylation in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation is linked to modulation of cardiac contraction. The sequence of human cardiac MyBP-C now reveals regulatory motifs specific for this isoform. Site-directed mutagenesis identifies a LAGGGRRIS loop in the N-terminal region of cardiac MyBP-C as the key substrate site for phosphorylation by both PKA and a calmodulin-dependent protein kinase associated with the native protein. Phosphorylation of two further sites by PKA is induced by phosphorylation of this isoform-specific site. This phosphorylation switch can be mimicked by aspartic acid instead of phosphoserine. Cardiac MyBP-C is therefore specifically equipped with sensors for adrenergic regulation of cardiac contraction, possibly implicating cardiac MyBP-C in cardiac disease. The gene coding for cardiac MyBP-C has been assigned to the chromosomal location 11p11.2 in humans, and is therefore in a region of physical linkage to subsets of familial hypertrophic cardiomyopathy (FHC). This makes cardiac MyBP-C a candidate gene for chromosome 11-associated FHC.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1100851, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1341033, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1404391, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1429890, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-152359, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1582406, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1671569, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1678777, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1688798, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1943760, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-1956339, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2108970, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2199796, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2315308, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2443804, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2453516, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2701214, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2726472, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2811944, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2812002, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2895634, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2903735, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2985470, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-2999980, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-3289571, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-352343, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-3543050, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-4269687, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6134729, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6141116, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6167505, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6214690, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6260526, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6276407, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6448079, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6546423, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6546932, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-6549009, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-7505783, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-7664083, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-7679114, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-7925935, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-7984417, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-8039496, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-8161531, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-8176743, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-8205619, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-8227129, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-8358441, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-8375400, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-8444471, http://linkedlifedata.com/resource/pubmed/commentcorrection/7744002-8449991
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1952-60
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
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