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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-6-15
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pubmed:abstractText |
About 50% of the mononuclear cells in the perivascular lesions in the central nervous system (CNS) of rats suffering from experimental allergic encephalomyelitis (EAE) are blood-borne macrophages. In this study we investigated the role of these macrophages in different variants of EAE, using a liposome-mediated macrophage depletion technique. Intravenously injected liposomes containing dichloromethylene diphosphonate (Cl2MDP) are ingested by macrophages and cause temporary and selective elimination of these cells. Macrophage depletion during EAE induced by a T cell line specific for myelin basic protein (MBP; T cell-EAE) suppresses development of neurological signs of EAE. T cell-EAE with pronounced demyelination as induced by an additionally injected MoAb directed against myelin oligodendrocyte glycoprotein (MOG) was also significantly ameliorated after macrophage depletion. During chronic relapsing EAE (CR-EAE) the occurrence of relapses was prevented or suppressed, provided that the liposomes were injected before the initiation of a putative relapse. A chronic progressive course of CR-EAE was not modified by Cl2MDP containing liposome treatment. Histologic examination of the CNS of liposome-treated animals confirmed decreased infiltration of macrophages into the parenchyma in the rats with T cell and AD-EAE, whereas T cells were still present.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-1398738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-1543728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-1993358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2141546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2145387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2239153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2332482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2389682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2413070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2476195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2530286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2662286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-2926837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-3257496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-3276004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-3390170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-3485656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-3494747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-3500978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-6168690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-6207204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-6256443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-6967418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-7174784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-7527745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-8083524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-8189065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-8285595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7743675-8449218
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
100
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
344-51
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7743675-Animals,
pubmed-meshheading:7743675-Clodronic Acid,
pubmed-meshheading:7743675-Cyclosporine,
pubmed-meshheading:7743675-Demyelinating Diseases,
pubmed-meshheading:7743675-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:7743675-Macrophages,
pubmed-meshheading:7743675-Male,
pubmed-meshheading:7743675-Rats,
pubmed-meshheading:7743675-Rats, Inbred Lew,
pubmed-meshheading:7743675-T-Lymphocytes
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pubmed:year |
1995
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pubmed:articleTitle |
Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats.
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pubmed:affiliation |
Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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