Linked Life Data

7742792

Source:http://linkedlifedata.com/resource/pubmed/id/7742792

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-6-15
pubmed:abstractText
In the isolated vas deferens of the guinea pig, the inhibitory effect of manganese (Mn2+) on contractions induced by norepinephrine decreased when the contractions were induced repeatedly in the presence of Mn2+. This phenomenon, "tachyphylaxis" to the inhibitory effect of Mn2+, was minimally observed when contractions were induced by acetylcholine. Contractions induced by acetylcholine as well as by norepinephrine in a Mn(2+)-free medium were augmented in preparations in which manganese had accumulated intracellularly by repetitive applications of high potassium in the presence of Mn2+. The magnitudes of their augmentation were dependent on the manganese contents of the preparations. The augmented contractions were remarkably resistant to the inhibitory effect of Mn2+ applied to the medium. These results suggest that intracellular manganese augments the contractions and this augmentation results in an apparent decrease in the inhibitory effect of Mn2+ in the medium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0918-6158
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
246-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Mechanism of tachyphylaxis on the inhibitory effect of manganese on agonist-induced contractions in the isolated vas deferens of the guinea pig.
pubmed:affiliation
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
pubmed:publicationType
Journal Article, In Vitro