Linked Life Data

7741857

Source:http://linkedlifedata.com/resource/pubmed/id/7741857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8939-8940
pubmed:dateCreated
1995-1-19
pubmed:abstractText
The role of cytomegalovirus infection in allograft injury is controversial. A subgroup of renal graft recipients who had histologically proven late-acute rejection did not respond to conventional anti-rejection therapy (80% graft loss within 1 year). These patients showed an expansion of memory-type CD8 peripheral-blood T cells that expressed interferon-gamma mRNA and an association with clinically symptomless cytomegalovirus infection (82% PCR positive, 42% antigenaemia). Antiviral therapy with ganciclovir resulted in stable improved graft function in 17 of 21 treated patients with cytomegalovirus-associated late-acute rejection. The results underline the clinical relevance of cytomegalovirus-related graft injury and offer a novel therapeutic approach.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:issn
0140-6736
pubmed:author
pubmed:issnType
Print
pubmed:volume
344
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1737-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Late-acute renal allograft rejection and symptomless cytomegalovirus infection.
pubmed:affiliation
Medical Clinic V-Nephrology, Universitätsklinikum Charité, Berlin, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't