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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-6-7
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pubmed:abstractText |
The lower blood pressure of vegetarians might partly be due to the high dietary load with nitrate which--to a certain extent--is further reduced to nitrite and finally to nitric oxide. To test this hypothesis, spontaneously hypertensive rats received drinking water containing 0, 25, 50 or 100 mmol/l NO2 during 56 days. Food was offered ad libitum or was restricted by 20% (pair-feeding) to simulate the lower energy consumption of vegetarians. Blood pressure, which was monitored at regular intervals, was lowered in a dose-dependent manner by nitrite. This effect was reversible and could not be enhanced by energy restriction. In volunteers plasma nitrate levels increased by a factor of 8 to 32 following the ingestion of a nitrate-rich meal, and mean methemoglobin concentrations increased from 1.2% to 2.4% indicating the endogenous formation of nitrite under these conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0004-4172
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
258-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7741780-Adult,
pubmed-meshheading:7741780-Animals,
pubmed-meshheading:7741780-Antihypertensive Agents,
pubmed-meshheading:7741780-Blood Pressure,
pubmed-meshheading:7741780-Body Weight,
pubmed-meshheading:7741780-Chromatography, High Pressure Liquid,
pubmed-meshheading:7741780-Diet, Vegetarian,
pubmed-meshheading:7741780-Energy Metabolism,
pubmed-meshheading:7741780-Female,
pubmed-meshheading:7741780-Humans,
pubmed-meshheading:7741780-Male,
pubmed-meshheading:7741780-Methemoglobin,
pubmed-meshheading:7741780-Nitrates,
pubmed-meshheading:7741780-Nitric Oxide,
pubmed-meshheading:7741780-Nitrites,
pubmed-meshheading:7741780-Rats,
pubmed-meshheading:7741780-Rats, Inbred SHR,
pubmed-meshheading:7741780-Rats, Sprague-Dawley,
pubmed-meshheading:7741780-Spectrophotometry, Ultraviolet
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pubmed:year |
1995
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pubmed:articleTitle |
Antihypertensive effect of oral nitrite uptake in the spontaneously hypertensive rat.
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pubmed:affiliation |
Department of Pharmacology and Toxicology of Nutrition, University of Hohenheim, Stuttgart, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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