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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-6-2
|
| pubmed:abstractText |
This study reports on the biological data of ten patients with acute venous thrombo-embolism. They were treated for 5 days with continuous intravenous infusion of a fixed dose (0.05 mg/kg/hr) of a recombinant hirudin (r-H HBW 023 Behringwerke, Germany). The plasma level of r-H (HBW 023), assessed by an anti-factor IIa amidolytic activity, was stable after Day 2 and showed considerable individual variations. It correlated with APTT ratio, suggesting that this test is a reliable tool to monitor therapy. In contrast, thrombin time was constantly over 120 sec (control 15 sec) and consequently was not a useful parameter. Prothrombin time showed a slight, but significant, prolongation, which was correlated with the increase of APTT ratio. There was no bleeding time prolongation, platelet count, or ATIII level decrease. Levels of thrombin-antithrombin III complexes, and D-dimers, which were high in all patients on admission, decreased during the course of the treatment but remained abnormal on Day 5, showing an ongoing hemostasis and fibrinolysis activation: this is consistent with the delayed, but only slightly decreased thrombin generation evidenced by thrombin generation test performed on Day 3. These results suggest that thrombin inhibition by rH-hirudin at this dosage is only partial, which allows the generation of traces of thrombin needed for the feed-back thrombin production generated by factor V and VIII activation.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antithrombin III,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Hirudins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Hydrolases,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Thrombin,
http://linkedlifedata.com/resource/pubmed/chemical/antithrombin III-protease complex
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0361-8609
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
67-72
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7741141-Adult,
pubmed-meshheading:7741141-Aged,
pubmed-meshheading:7741141-Aged, 80 and over,
pubmed-meshheading:7741141-Antithrombin III,
pubmed-meshheading:7741141-Biological Markers,
pubmed-meshheading:7741141-Female,
pubmed-meshheading:7741141-Hemostasis,
pubmed-meshheading:7741141-Hirudin Therapy,
pubmed-meshheading:7741141-Hirudins,
pubmed-meshheading:7741141-Humans,
pubmed-meshheading:7741141-Infusions, Intravenous,
pubmed-meshheading:7741141-Male,
pubmed-meshheading:7741141-Middle Aged,
pubmed-meshheading:7741141-Partial Thromboplastin Time,
pubmed-meshheading:7741141-Peptide Hydrolases,
pubmed-meshheading:7741141-Prothrombin Time,
pubmed-meshheading:7741141-Recombinant Proteins,
pubmed-meshheading:7741141-Reference Values,
pubmed-meshheading:7741141-Thrombin,
pubmed-meshheading:7741141-Thrombin Time,
pubmed-meshheading:7741141-Thromboembolism,
pubmed-meshheading:7741141-Time Factors
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Recombinant hirudin (HBW 023): biological data of ten patients with severe venous thrombo-embolism.
|
| pubmed:affiliation |
Department of Hematology, Hôpital A. Béclère, Paris, France.
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| pubmed:publicationType |
Journal Article
|