Linked Life Data

7739916

Source:http://linkedlifedata.com/resource/pubmed/id/7739916

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-6-5
pubmed:abstractText
Diets high in fat and low in dietary fiber have been associated with a higher incidence of colon cancer, possibly by increasing bile acid concentration in the colon. Therefore changes in bile acid metabolism due to beef tallow, corn bran (CB), and soy polysaccharide (SP) feeding were studied. Rats were fed one of four diets for six weeks: 5% beef tallow fiber-free (LF), 20% beef tallow fiber-free (HF), 20% beef tallow with CB (HFCB), and 20% beef tallow with SP (HFSP). HF increased fecal output compared with LF, and HFCB and HFSP increased fecal output compared with HF. HF reduced fecal bile acid concentration by two-thirds compared with LF, although daily bile acid excretion was similar. There was a tendency toward a smaller bile acid quantity in the small intestine with HF than with LF. Neither fiber altered total fecal bile acid concentration or small intestinal bile acid quantity compared with HF. However, 7 alpha-dehydroxylase activity in the colon was lower with HFSP than with HFCB. Increasing dietary beef tallow from 5% to 20% in animals fed a fiber-free diet greatly reduced the concentration of bile acids in the large intestine and feces, an effect associated with a reduced risk of colon cancer.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0163-5581
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
63-75
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Beef tallow, but not corn bran or soybean polysaccharide, reduces large intestinal and fecal bile acid concentrations in rats.
pubmed:affiliation
Department of Food Science and Nutrition, University of Minnesota, St. Paul 55108, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.