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pubmed-article:7738663pubmed:abstractTextAntibody fragments labeled with a radiometal using bifunctional chelates generally undergo renal clearance followed by trapping of the metabolites, leading to high radiation doses to the kidneys. Copper-64-labeled BAT-2IT-1A3-F(ab')2 was recently reported to accumulate in colorectal tumors in an animal model, however, kidney uptake was also high. In this study, the preparation of 64Cu-BAT-2IT-1A3-F(ab')2 was optimized to reduce the renal uptake.lld:pubmed
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pubmed-article:7738663pubmed:articleTitlePreparation, biodistribution and dosimetry of copper-64-labeled anti-colorectal carcinoma monoclonal antibody fragments 1A3-F(ab')2.lld:pubmed
pubmed-article:7738663pubmed:affiliationMallinckrodt Institute of Radiology, St Louis, MO 63110, USA.lld:pubmed
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pubmed-article:7738663pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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