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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-6-5
|
| pubmed:abstractText |
Antibody fragments labeled with a radiometal using bifunctional chelates generally undergo renal clearance followed by trapping of the metabolites, leading to high radiation doses to the kidneys. Copper-64-labeled BAT-2IT-1A3-F(ab')2 was recently reported to accumulate in colorectal tumors in an animal model, however, kidney uptake was also high. In this study, the preparation of 64Cu-BAT-2IT-1A3-F(ab')2 was optimized to reduce the renal uptake.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0161-5505
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
36
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
850-8
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7738663-Animals,
pubmed-meshheading:7738663-Antibodies, Monoclonal,
pubmed-meshheading:7738663-Colorectal Neoplasms,
pubmed-meshheading:7738663-Copper Radioisotopes,
pubmed-meshheading:7738663-Cricetinae,
pubmed-meshheading:7738663-Immunoglobulin Fragments,
pubmed-meshheading:7738663-Mesocricetus,
pubmed-meshheading:7738663-Papio,
pubmed-meshheading:7738663-Rats,
pubmed-meshheading:7738663-Rats, Sprague-Dawley,
pubmed-meshheading:7738663-Tissue Distribution
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Preparation, biodistribution and dosimetry of copper-64-labeled anti-colorectal carcinoma monoclonal antibody fragments 1A3-F(ab')2.
|
| pubmed:affiliation |
Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|