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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1995-6-5
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pubmed:abstractText |
The anti-inflammatory drug sodium salicylate modulates the activity of specific transcription factors in humans. Here we show that salicylate and sorbate, another organic acid, stimulate DNA binding by yeast heat shock transcription factor (HSF) in vivo. Surprisingly, salicylate inhibits heat shock gene transcription even in cells induced by a prior heat shock. This inhibition of transcription occurs at a step after HSF and transcription factor IID binding but before promoter melting by RNA polymerase. Salicylate appears to generate a tight binding but activation-impotent HSF by cytoplasmic acidification, since inhibiting proton efflux from cells triggers this same DNA binding and inhibition of heat shock gene expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
270
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pubmed:geneSymbol |
HSP82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10369-72
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pubmed:dateRevised |
2009-7-15
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pubmed:meshHeading |
pubmed-meshheading:7737966-Base Sequence,
pubmed-meshheading:7737966-Binding Sites,
pubmed-meshheading:7737966-DNA Primers,
pubmed-meshheading:7737966-DNA-Binding Proteins,
pubmed-meshheading:7737966-Gene Expression Regulation, Fungal,
pubmed-meshheading:7737966-Heat-Shock Proteins,
pubmed-meshheading:7737966-Hydrogen-Ion Concentration,
pubmed-meshheading:7737966-Molecular Sequence Data,
pubmed-meshheading:7737966-Nucleic Acid Denaturation,
pubmed-meshheading:7737966-Promoter Regions, Genetic,
pubmed-meshheading:7737966-Saccharomyces cerevisiae,
pubmed-meshheading:7737966-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:7737966-Sodium Salicylate,
pubmed-meshheading:7737966-Sorbic Acid,
pubmed-meshheading:7737966-Transcription, Genetic,
pubmed-meshheading:7737966-Transcription Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Sodium salicylate and yeast heat shock gene transcription.
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pubmed:affiliation |
Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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