Linked Life Data

7734740

Source:http://linkedlifedata.com/resource/pubmed/id/7734740

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-6-8
pubmed:abstractText
We randomized 102 patients with insulin-dependent diabetes to intensified treatment (n = 48 at baseline, n = 42 after 7.5 years) or standard treatment (n = 54 at baseline, n = 47 after 7.5 years). As has previously been reported, intensified treatment resulted in a retardation of retinopathy, nephropathy, and neuropathy. For the purpose of the present study, all patients were analyzed, and the complications related to the mean glycosylated hemoglobin (HbA1c) level. Patients with mild retinopathy at onset did not develop serious retinopathy, visual deterioration, or manifest nephropathy if their mean HbA1c during 7.5 years was below 7% (normal range, 3.9%-5.7%). Neuropathy only rarely developed in patients with HbA1c below 7%. Visual acuity in the patient group with more advanced retinopathy at baseline was also better preserved if the patient had lower HbA1c; also whereas these patients needed photocoagulation treatment just as often as the patients with higher HbA1c because of proliferative retinopathy or sight-threatening macular edema. The risk for the development of serious and disabling microvascular complications seems to be small in patients with insulin-dependent diabetes mellitus if they start intensified treatment when they have mild retinopathy, and achieve mean HbA1c levels below 7% (1.2 times the upper normal limit).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1056-8727
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-30
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Are there any glycemic thresholds for the serious microvascular diabetic complications?
pubmed:affiliation
Department of Internal Medicine, Södersjukhuset, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't