|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1995-5-30
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
We isolated 8 genes whose expression is modulated during cardiac development. The expressions of 6 of these eight genes were modulated during the development of cardiac hypertrophy and/or during the transition to heart failure. In particular, the expression levels of the pro alpha-1 collagen, tissue type II transglutaminase, and vimentin genes were markedly increased during the transition to heart failure. Up-regulation of the pro alpha-1 collagen and vimentin genes may reflect activation of interstitial cells during the transition to heart failure. Up-regulation of the tissue type II transglutaminase gene during the transition to heart failure is intriguing, since this enzyme has been suggested to be involved in the activation of latent TGF-beta.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
17
|
|
pubmed:volume |
209
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
527-34
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:7733921-Amino Acid Sequence,
pubmed-meshheading:7733921-Animals,
pubmed-meshheading:7733921-Base Sequence,
pubmed-meshheading:7733921-Cardiomegaly,
pubmed-meshheading:7733921-Collagen,
pubmed-meshheading:7733921-GTP-Binding Proteins,
pubmed-meshheading:7733921-Gene Expression,
pubmed-meshheading:7733921-Heart,
pubmed-meshheading:7733921-Heart Failure,
pubmed-meshheading:7733921-Male,
pubmed-meshheading:7733921-Molecular Sequence Data,
pubmed-meshheading:7733921-Myosins,
pubmed-meshheading:7733921-RNA, Messenger,
pubmed-meshheading:7733921-Rats,
pubmed-meshheading:7733921-Rats, Sprague-Dawley,
pubmed-meshheading:7733921-Sequence Alignment,
pubmed-meshheading:7733921-Sequence Homology, Amino Acid,
pubmed-meshheading:7733921-Transglutaminases,
pubmed-meshheading:7733921-Vimentin
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Genes up-regulated in hypertrophied ventricle.
|
|
pubmed:affiliation |
1st Department of Internal Medicine, Shiga University of Medical Sciences, Ohtsu-city, Japan.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
