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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1995-5-30
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pubmed:abstractText |
We conducted a study to determine whether increasing vitamin D intake above the recommended dietary allowance (RDA) of 5.0 micrograms (200 IU)/d reduces bone loss in healthy postmenopausal women residing at latitude 42 degrees N. In this double-blind, randomized 2-y trial, we enrolled 247 healthy ambulatory postmenopausal women who consumed an average of 2.5 micrograms (100 IU) vitamin D/d in their usual diets. The women were given either 2.5 micrograms (100 IU) or 17.5 micrograms (700 IU) vitamin D/d. All women received 500 mg supplemental calcium per day as citrate malate. Duplicate hip and spine and single whole-body scans were performed by dual-energy x-ray absorptiometry at 6-mo intervals selected to flank the periods when 25-hydroxycholecalciferol (calcidiol) concentrations are highest (summer/fall) and lowest (winter/spring). Plasma calcidiol and serum osteocalcin were measured in these seasons in year 1. Both treatment groups lost bone mineral density from the femoral neck, but the 17.5-micrograms group lost less than (-1.06 +/- 0.34%; mean +/- SE) the 2.5-micrograms group (-2.54 +/- 0.37%, P = 0.003). Seventy percent of the benefit each year occurred in winter/spring and 30% in summer/fall. Changes in spinal and whole-body bone densities did not differ by treatment group and were minimal after 2 y. Serum osteocalcin and plasma calcidiol (2.5-micrograms group only) fluctuated with season. In conclusion, in healthy, calcium-supplemented, postmenopausal women residing at latitude 42 degrees N, an intake of 5.0 micrograms (200 IU) vitamin D/d is sufficient to limit bone loss from the spine and whole body but it is not adequate to minimize bone loss from the femoral neck.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0002-9165
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1140-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7733040-Aged,
pubmed-meshheading:7733040-Bone Density,
pubmed-meshheading:7733040-Bone and Bones,
pubmed-meshheading:7733040-Calcifediol,
pubmed-meshheading:7733040-Diet,
pubmed-meshheading:7733040-Dose-Response Relationship, Drug,
pubmed-meshheading:7733040-Double-Blind Method,
pubmed-meshheading:7733040-Female,
pubmed-meshheading:7733040-Femur Neck,
pubmed-meshheading:7733040-Humans,
pubmed-meshheading:7733040-Middle Aged,
pubmed-meshheading:7733040-Nutritional Requirements,
pubmed-meshheading:7733040-Osteocalcin,
pubmed-meshheading:7733040-Osteoporosis, Postmenopausal,
pubmed-meshheading:7733040-Seasons,
pubmed-meshheading:7733040-Spine,
pubmed-meshheading:7733040-Vitamin D
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pubmed:year |
1995
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pubmed:articleTitle |
Rates of bone loss in postmenopausal women randomly assigned to one of two dosages of vitamin D.
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pubmed:affiliation |
USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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