Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1995-6-1
pubmed:abstractText
We present data on the decay, after radiotherapy, of naive and memory human T lymphocytes with stable chromosome damage. These data are analyzed in conjunction with existing data on the decay of naive and memory T lymphocytes with unstable chromosome damage and older data on unsorted lymphocytes. The analyses yield in vivo estimates for some life-history parameters of human T lymphocytes. Best estimates of proliferation rates have naive lymphocytes dividing once every 3.5 years and memory lymphocytes dividing once every 22 weeks. It appears that memory lymphocytes can revert to the naive phenotype, but only, on average, after 3.5 years in the memory class. The lymphocytes with stable chromosome damage decay very slowly, yielding surprisingly low estimates of their death rate. The estimated parameters are used in a simple mathematical model of the population dynamics of undamaged naive and memory lymphocytes. We use this model to illustrate that it is possible for the unprimed subset of a constantly stimulated clone to stay small, even when there is a large population of specific primed cells reverting to the unprimed state.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-14248553, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-1436108, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-1671403, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-1834549, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-1834764, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-1978253, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-2191683, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-2307933, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-2477327, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-2965180, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-2974420, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-6032868, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-7516038, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-7516039, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-8073282, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-8104315, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-8143116, http://linkedlifedata.com/resource/pubmed/commentcorrection/7731969-8442858
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3707-11
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
In vivo estimates of division and death rates of human T lymphocytes.
pubmed:affiliation
Zoology Department, University of Oxford, United Kingdom.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't