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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-6-1
|
| pubmed:abstractText |
The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cases with histologically confirmed CIN II-III and 234 age-matched and randomly selected controls. Cytological specimens from the cervix were analyzed using the polymerase chain reaction (PCR). In all, 91% of the cases and 15% of the controls were HPV DNA positive, giving a crude odds ratio (OR) of 67.2 (95% confidence interval: 28.6-157.5). The association between HPV 16 and CIN II-III was even stronger (crude OR = 123.9; 46.7 - 328.5). In logistic regression analysis, additional to HPV, only a high number of sexual partners and a low educational level contributed independently to the risk. The adjusted OR for the association between HPV and CIN II-III was 72.8 (95% CI: 27.6-191.9). The association between HPV and CIN remains very strong even after adjustment for proposed confounding factors. The results therefore support the role of HPV as a causative agent in the development of CIN.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0020-7136
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
4
|
| pubmed:volume |
61
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
312-5
|
| pubmed:dateRevised |
2007-7-24
|
| pubmed:meshHeading |
pubmed-meshheading:7729940-Adult,
pubmed-meshheading:7729940-Age Factors,
pubmed-meshheading:7729940-Analysis of Variance,
pubmed-meshheading:7729940-Case-Control Studies,
pubmed-meshheading:7729940-Cervical Intraepithelial Neoplasia,
pubmed-meshheading:7729940-DNA, Viral,
pubmed-meshheading:7729940-Female,
pubmed-meshheading:7729940-Humans,
pubmed-meshheading:7729940-Medical History Taking,
pubmed-meshheading:7729940-Menarche,
pubmed-meshheading:7729940-Multivariate Analysis,
pubmed-meshheading:7729940-Norway,
pubmed-meshheading:7729940-Papillomaviridae,
pubmed-meshheading:7729940-Papillomavirus Infections,
pubmed-meshheading:7729940-Polymerase Chain Reaction,
pubmed-meshheading:7729940-Random Allocation,
pubmed-meshheading:7729940-Sexual Behavior,
pubmed-meshheading:7729940-Tumor Virus Infections,
pubmed-meshheading:7729940-Uterine Cervical Neoplasms,
pubmed-meshheading:7729940-Vaginal Smears
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Human papillomavirus and cervical intraepithelial neoplasia grade II-III: a population-based case-control study.
|
| pubmed:affiliation |
Department of Epidemiology, National Institute of Public Health, Oslo, Norway.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|