| pubmed-article:7729618 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7729618 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:7729618 | lifeskim:mentions | umls-concept:C0037993 | lld:lifeskim |
| pubmed-article:7729618 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:7729618 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:7729618 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:7729618 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:7729618 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7729618 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7729618 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7729618 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7729618 | pubmed:dateCreated | 1995-5-31 | lld:pubmed |
| pubmed-article:7729618 | pubmed:abstractText | It has been reported that the level of Tap-1 (transporter associated with antigen processing) mRNA and the expression of class I on splenocytes are low in NOD mice. Class I expression at 37 degrees C depends on an adequate supply of peptides, so a decrease in Tap could lead to lower class I levels. Since hypoexpression of class I correlated uniformly with the development of diabetes, it has also been suggested that Tap-1nod is diabetogenic. However, others report normal Tap-1 and class I levels in NOD mice. We examined Tap-1 and Tap-2 mRNA levels in NOD/Smrf mice using a reverse transcriptase-polymerase chain reaction method that detects > or = 25% changes in mRNA. We also assessed class I expression with three monoclonal antibodies. No difference in Tap-1 or Tap-2 mRNA levels for females of different ages or between diabetic and nondiabetic animals was observed. Tap-1 mRNA levels were identical between NOD/Smrf and BALB/cJ mice. Kd expression was significantly lower on NOD lymphocytes than in BALB/cJ cells, but the difference was due to the smaller size of the NOD splenic lymphocyte. When cells of the same size were analyzed, no difference in class I levels was observed. Class I levels were also identical in diabetic and age-matched nondiabetic NOD and BALB/c females. Both NOD Tap-1 mRNA and class I were increased by interferon-gamma. We find no evidence for impaired NOD Tap gene activity or class I expression, as previously reported for this strain. | lld:pubmed |
| pubmed-article:7729618 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7729618 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7729618 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7729618 | pubmed:month | May | lld:pubmed |
| pubmed-article:7729618 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:7729618 | pubmed:author | pubmed-author:ChenH MHM | lld:pubmed |
| pubmed-article:7729618 | pubmed:author | pubmed-author:PetersonC MCM | lld:pubmed |
| pubmed-article:7729618 | pubmed:author | pubmed-author:PearceR BRB | lld:pubmed |
| pubmed-article:7729618 | pubmed:author | pubmed-author:TriglerLL | lld:pubmed |
| pubmed-article:7729618 | pubmed:author | pubmed-author:SvaasandE KEK | lld:pubmed |
| pubmed-article:7729618 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7729618 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:7729618 | pubmed:geneSymbol | Tap-1 | lld:pubmed |
| pubmed-article:7729618 | pubmed:geneSymbol | Tap-2 | lld:pubmed |
| pubmed-article:7729618 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7729618 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7729618 | pubmed:pagination | 572-9 | lld:pubmed |
| pubmed-article:7729618 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:meshHeading | pubmed-meshheading:7729618-... | lld:pubmed |
| pubmed-article:7729618 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7729618 | pubmed:articleTitle | Levels of Tap-1 and Tap-2 mRNA and expression of Kd and Db on splenic lymphocytes are normal in NOD mice. | lld:pubmed |
| pubmed-article:7729618 | pubmed:affiliation | Sansum Medical Research Foundation, Santa Barbara, CA 93105, USA. | lld:pubmed |
| pubmed-article:7729618 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7729618 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:21354 | entrezgene:pubmed | pubmed-article:7729618 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7729618 | lld:pubmed |
