rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1995-5-26
|
pubmed:abstractText |
A novel heat-stable enterotoxin (ST) designated as Y-STc was purified to homogeneity from the culture supernatant of a pathogenic strain of Yersinia enterocolitica serotype O3 and its amino acid sequence was determined. The mature Y-STc was found to consist of 53 amino acid residues, which includes the putative pro-sequence. The molecular weight of Y-STc was 5638 and constituted the largest molecular size in the family of currently known STs. The minimum effective dose of purified Y-STc in the suckling mouse assay was 0.6 ng (0.0 pmol), indicating that, despite the long sequence, Y-STc is the most toxic in the ST family.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0014-5793
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
10
|
pubmed:volume |
362
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
319-22
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7729521-Amino Acid Sequence,
pubmed-meshheading:7729521-Amino Acids,
pubmed-meshheading:7729521-Animals,
pubmed-meshheading:7729521-Animals, Suckling,
pubmed-meshheading:7729521-Bacterial Toxins,
pubmed-meshheading:7729521-Conserved Sequence,
pubmed-meshheading:7729521-Enterotoxins,
pubmed-meshheading:7729521-Genes, Bacterial,
pubmed-meshheading:7729521-Mice,
pubmed-meshheading:7729521-Molecular Sequence Data,
pubmed-meshheading:7729521-Molecular Weight,
pubmed-meshheading:7729521-Protein Precursors,
pubmed-meshheading:7729521-Sequence Alignment,
pubmed-meshheading:7729521-Sequence Analysis,
pubmed-meshheading:7729521-Yersinia enterocolitica
|
pubmed:year |
1995
|
pubmed:articleTitle |
Characterization of a highly toxic, large molecular size heat-stable enterotoxin produced by a clinical isolate of Yersinia enterocolitica.
|
pubmed:affiliation |
Institute for Protein Research, Osaka University, Japan.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|