Linked Life Data

7728959

Source:http://linkedlifedata.com/resource/pubmed/id/7728959

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-5-30
pubmed:abstractText
The induction of apurinic/apyrimidinic sites (AP sites) and DNA single-strand breaks (SSB) by chromate and glutathione in isolated DNA was investigated using agents that cleave the DNA at AP sites (putrescine and exonuclease III). It was found that chromate/glutathione-induced AP sites contain free aldehyde groups, as cleavage by putrescine could be prevented by treatment with sodium borohydride. The formation of AP sites and SSB followed a very similar temporal pattern, suggesting that both lesions arise from attack by the same single reactive species deriving from chromate and glutathione. Furthermore, the induction of both lesions was found to be dependent on the presence of molecular oxygen.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0143-3334
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
805-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
The formation of both apurinic/apyrimidinic sites and single-strand breaks by chromate and glutathione arises from attack by the same single reactive species and is dependent on molecular oxygen.
pubmed:affiliation
Department of Toxicology, School of Pharmacy, University of London, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't