Linked Life Data

7727685

Source:http://linkedlifedata.com/resource/pubmed/id/7727685

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-6-1
pubmed:abstractText
Interleukin-1 (IL-1) is primarily an inflammatory cytokine. Biologically, IL-1 is more closely related to tumor necrosis factor (TNF) than any other cytokine or interleukin, although the structure and receptors for IL-1 and TNF are clearly distinct. IL-1 is active in the low pM and fM range and IL-1 receptors (IL-1R) are expressed in most cells, although less than 100 receptors per cell is not an uncommon finding. Based on short-term blockade of IL-1 receptors in humans and animals and IL-1 beta knock-out mice, there is no evidence that IL-1 beta plays a role in development, or normal homeostasis such as metabolism, hematopoiesis, renal and hepatic function or regulation of blood pressure. On the other hand, IL-1 alpha is found constitutively produced by various epithelial cells, keratinocytes of the skin and in the brain. In these locations, IL-1 may contribute to cell growth and repair functions. During inflammation, injury, immunological challenge or infection, IL-1 is produced and because of its multiple biological properties, IL-1 must contribute to disease. Most studies on IL-1 are derived from experiments in which humans or animals are injected with IL-1 or IL-1 is added to cells in vitro. The biological properties of IL-1 suggest that its effects often mimic host responses to infection, inflammation, injury or immunologic challenge. Using specific IL-1 blockade, it is clear IL-1 is playing a critical role in some disease processes. This review will focus on IL-1 as a cytokine of primary and strategic importance to the initiation and progression of inflammatory and infectious diseases.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1148-5493
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
517-31
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
The biological properties of interleukin-1.
pubmed:affiliation
Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Review