| pubmed-article:7727536 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7727536 | lifeskim:mentions | umls-concept:C0031849 | lld:lifeskim |
| pubmed-article:7727536 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:7727536 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7727536 | lifeskim:mentions | umls-concept:C1185625 | lld:lifeskim |
| pubmed-article:7727536 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:7727536 | lifeskim:mentions | umls-concept:C0039245 | lld:lifeskim |
| pubmed-article:7727536 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:7727536 | pubmed:dateCreated | 1995-5-31 | lld:pubmed |
| pubmed-article:7727536 | pubmed:abstractText | Tacrine (THA) and physostigmine (PHS) have been used in Alzheimer's disease therapy for their anticholinesterasic activity. Here we show that THA is taken up in rat lysosomes in an energy-dependent manner, and that it is also accumulated in acidic compartments of rat thymocytes and neuroblastoma cells. A concentration of THA less than 1 mM dissipated the pH gradient (delta pH) in all the above mentioned in vitro systems. On the contrary higher concentrations of PHS (1-2 mM) were ineffective. The accumulation of THA in acidic organelles of the cell may be relevant for the pharmacological action of THA in Alzheimer's treatment. | lld:pubmed |
| pubmed-article:7727536 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7727536 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7727536 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7727536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7727536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7727536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7727536 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7727536 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7727536 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:7727536 | pubmed:author | pubmed-author:BragadinMM | lld:pubmed |
| pubmed-article:7727536 | pubmed:author | pubmed-author:Dell'AntonePP | lld:pubmed |
| pubmed-article:7727536 | pubmed:author | pubmed-author:ZattaPP | lld:pubmed |
| pubmed-article:7727536 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7727536 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:7727536 | pubmed:volume | 1270 | lld:pubmed |
| pubmed-article:7727536 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7727536 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7727536 | pubmed:pagination | 137-41 | lld:pubmed |
| pubmed-article:7727536 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
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| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:meshHeading | pubmed-meshheading:7727536-... | lld:pubmed |
| pubmed-article:7727536 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7727536 | pubmed:articleTitle | Anticholinesterasic drugs: tacrine but not physostigmine, accumulates in acidic compartments of the cells. | lld:pubmed |
| pubmed-article:7727536 | pubmed:affiliation | Dipartimento di Scienze Biomediche Sperimentali, Università and di Padova, Italy. | lld:pubmed |
| pubmed-article:7727536 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7727536 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7727536 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7727536 | lld:pubmed |
