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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-6-1
|
| pubmed:abstractText |
Von Willebrand factor antigen (vWF Ag) is a marker of endothelial injury which has been shown to rise during surgical procedures, including cardiopulmonary bypass (CPB). The aim of this study was to determine whether intermittent aortic cross-clamping during CPB causes the release of vWF Ag from the coronary vascular bed, which would suggest coronary vascular endothelial cell perturbation. Fifteen consecutive patients undergoing CPB with aortic cross-clamping during coronary artery bypass surgery and/or valve replacement by the same surgeon were studied. Paired venous and coronary sinus samples were taken pre- and post-thoracotomy, prior to cross-clamping on CPB, and 1, 5 and 10 minutes after release of the aortic cross-clamp. Plasma vWF Ag (IU/ml) was measured by ELISA. Venous vWF Ag measured prior to skin incision was 0.75 +/- 0.11 IU/ml (mean +/- SEM) and fell to 0.53 +/- 0.07 IU/ml after institution of CPB but prior to aortic cross-clamping (P < 0.01 vs pre-incision sample). Coronary sinus vWF Ag measured prior to aortic cross-clamping was 0.54 +/- 0.06 IU/ml (P = NS vs paired venous sample). At 1, 5 and 10 min after release of the aortic cross-clamp there was a progressive rise in vWF Ag in both venous and coronary sinus samples (1 min: 0.67 +/- 0.05 IU/ml vs 0.75 +/- 0.10 IU/ml, 5 min: 0.73 +/- 0.07 IU/ml vs 0.76 +/- 0.09 IU/ml, 10 min: 0.74 +/- 0.08 IU/ml vs 0.79 +/- 0.09 IU/ml; P = NS venous vs coronary sinus, respectively). Levels of vWF Ag were highest immediately prior to the termination of CPB (venous: 0.95 +/- 0.12 IU/ml; coronary sinus: 0.91 +/- 0.14 IU/ml). We conclude that cardiac surgery using CPB with aortic cross-clamping is associated with a progressive rise in coronary sinus and venous levels of vWF Ag.(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Creatine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Von Willebrand antigen,
http://linkedlifedata.com/resource/pubmed/chemical/von Willebrand Factor
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1010-7940
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
18-21
|
| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:7727141-Adult,
pubmed-meshheading:7727141-Aged,
pubmed-meshheading:7727141-Analysis of Variance,
pubmed-meshheading:7727141-Antigens,
pubmed-meshheading:7727141-Aortic Valve,
pubmed-meshheading:7727141-Biological Markers,
pubmed-meshheading:7727141-Cardiopulmonary Bypass,
pubmed-meshheading:7727141-Constriction,
pubmed-meshheading:7727141-Coronary Vessels,
pubmed-meshheading:7727141-Creatine Kinase,
pubmed-meshheading:7727141-Endothelium, Vascular,
pubmed-meshheading:7727141-Heart Valve Prosthesis,
pubmed-meshheading:7727141-Hematocrit,
pubmed-meshheading:7727141-Humans,
pubmed-meshheading:7727141-Isoenzymes,
pubmed-meshheading:7727141-Middle Aged,
pubmed-meshheading:7727141-Mitral Valve,
pubmed-meshheading:7727141-Postoperative Care,
pubmed-meshheading:7727141-Preoperative Care,
pubmed-meshheading:7727141-Veins,
pubmed-meshheading:7727141-von Willebrand Factor
|
| pubmed:year |
1995
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| pubmed:articleTitle |
The effects of cardiopulmonary bypass on systemic and coronary levels of von Willebrand factor.
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| pubmed:affiliation |
Royal Brompton National Heart & Lung Hospital, London, UK.
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| pubmed:publicationType |
Journal Article
|