Linked Life Data

7726843

Source:http://linkedlifedata.com/resource/pubmed/id/7726843

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-25
pubmed:abstractText
Haptoglobin (HP) is the major hemoglobin binding protein which is synthesized mainly in the liver. It functions to prevent iron loss and kidney damage in human and other mammals. Recently, HP has been shown to possess antioxidant and angiogenic properties. As one of the major acute phase reactants, HP's levels in plasma increase significantly during inflammation, infection and malignancy. In this study, high levels of HP mRNA were found to be transcribed by adipocytes in addition to liver cells in mice. After inflammation had been induced in vivo, expression of the haptoglobin gene rose six-fold in adipose tissue, an increase compatible with that observed in the normal mouse liver. The expression of HP by adipocytes presents new directions in which HP's role as an antioxidant or as an angiogenic factor can be investigated.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
209
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
250-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Expression and inflammatory regulation of haptoglobin gene in adipocytes.
pubmed:affiliation
Department of Cellular and Structural Biology, University of Texas, Health Science Center at San Antonio 78284, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.