rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1995-5-25
|
pubmed:abstractText |
Endothelin-1 is a potent vasoactive peptide which may play a role in the regulation of vascular resistance through its autocrine/paracrine effects. We have investigated the influence of salt loading on the renal and cardiac production of endothelin-1 in stroke prone spontaneously hypertensive rats, a classical model of hypertension. The results show that the dietary salt intake did not change systolic blood pressure nor the renal expression of the preproendothelin-1 mRNA but increased cardiac expression of the endothelin-1 gene transcript and a concomitant ventricular hypertrophy.
|
pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0006-291X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
6
|
pubmed:volume |
209
|
pubmed:geneSymbol |
ET-1
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
161-6
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7726830-Animals,
pubmed-meshheading:7726830-Blotting, Northern,
pubmed-meshheading:7726830-Cerebrovascular Disorders,
pubmed-meshheading:7726830-Endothelin-1,
pubmed-meshheading:7726830-Endothelins,
pubmed-meshheading:7726830-Genetic Predisposition to Disease,
pubmed-meshheading:7726830-Heart,
pubmed-meshheading:7726830-Kidney,
pubmed-meshheading:7726830-Myocardium,
pubmed-meshheading:7726830-Protein Precursors,
pubmed-meshheading:7726830-RNA, Messenger,
pubmed-meshheading:7726830-Rats,
pubmed-meshheading:7726830-Rats, Inbred SHR,
pubmed-meshheading:7726830-Sodium Chloride
|
pubmed:year |
1995
|
pubmed:articleTitle |
Influence of salt loading on the cardiac and renal preproendothelin-1 mRNA expression in stroke-prone spontaneously hypertensive rats.
|
pubmed:affiliation |
Laboratoire de Pharmacologie, Université Catholique de Louvain, UCL 5410, Brussels, Belgium.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|