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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1995-5-24
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pubmed:abstractText |
In a double-blind, placebo study, acetyl-L-carnitine was administered to 7 probable Alzheimer's disease patients who were then compared by clinical and 31P magnetic resonance spectroscopic measures to 5 placebo-treated probable AD patients and 21 age-matched healthy controls over the course of 1 year. Compared to AD patients on placebo, acetyl-L-carnitine-treated patients showed significantly less deterioration in their Mini-Mental Status and Alzheimer's Disease Assessment Scale test scores. Furthermore, the decrease in phosphomonoester levels observed in both the acetyl-L-carnitine and placebo AD groups at entry was normalized in the acetyl-L-carnitine-treated but not in the placebo-treated patients. Similar normalization of high-energy phosphate levels was observed in the acetyl-L-carnitine-treated but not in the placebo-treated patients. This is the first direct in vivo demonstration of a beneficial effect of a drug on both clinical and CNS neurochemical parameters in AD.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0197-4580
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7723928-Acetylcarnitine,
pubmed-meshheading:7723928-Aged,
pubmed-meshheading:7723928-Alzheimer Disease,
pubmed-meshheading:7723928-Double-Blind Method,
pubmed-meshheading:7723928-Energy Metabolism,
pubmed-meshheading:7723928-Female,
pubmed-meshheading:7723928-Humans,
pubmed-meshheading:7723928-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7723928-Male,
pubmed-meshheading:7723928-Middle Aged,
pubmed-meshheading:7723928-Phosphates,
pubmed-meshheading:7723928-Phospholipids
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pubmed:articleTitle |
Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer's disease.
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pubmed:affiliation |
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, PA 15213, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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