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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1995-5-25
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pubmed:abstractText |
Metastatic prostate cancer is a leading cause of cancer-related death in men. The rate of response to androgen ablation is high, but most patients relapse as a result of the outgrowth of androgen-independent tumor cells. The androgen receptor, which binds testosterone and stimulates the transcription of androgen-responsive genes, regulates the growth of prostate cells. We analyzed the androgen-receptor genes from samples of metastatic androgen-independent prostate cancers to determine whether mutations in the gene have a role in androgen independence.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0028-4793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
332
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1393-8
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:7723794-Base Sequence,
pubmed-meshheading:7723794-Bone Marrow Diseases,
pubmed-meshheading:7723794-DNA, Complementary,
pubmed-meshheading:7723794-DNA, Neoplasm,
pubmed-meshheading:7723794-Estradiol,
pubmed-meshheading:7723794-Humans,
pubmed-meshheading:7723794-Male,
pubmed-meshheading:7723794-Molecular Sequence Data,
pubmed-meshheading:7723794-Neoplasm Metastasis,
pubmed-meshheading:7723794-Point Mutation,
pubmed-meshheading:7723794-Prostatic Neoplasms,
pubmed-meshheading:7723794-Receptors, Androgen,
pubmed-meshheading:7723794-Testosterone,
pubmed-meshheading:7723794-Transcription, Genetic,
pubmed-meshheading:7723794-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer.
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pubmed:affiliation |
Department of Medicine, University of Massachusetts Medical Center, Worcester, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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