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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1976-7-6
|
| pubmed:abstractText |
The in utero effects of DES (Diethylstilbestrol) on the human male genital tract are reported in this follow-up study of male offspring of DES-treated mothers. Both anatomical and functional abnormalities were significantly greater in the DES-exposed males as compared to control males whose mothers were all participants in a prospective, randomized double blind study of the effects of DES on pregnancy at the Chicago Lying-in Hospital during the early 1950s. Epididymal cysts, hypotrophic testes and capsular induration of the testes were among the more common genital lesions found in 27% of 134 DES-exposed males as compared to a 7% incidence in 119 control males. Spermatozoa analyses revealed severely pathologic changes (Eliasson score greater than 10) in 29% of 28 DES-exposed males and 0% of 18 control males (with or without genital i.e., physical abnormalities). Abnormal findings on physical examination combined with sperm abnormalities (Eliasson score greater than or equal to 5) were found in 29% of DES-exposed males versus 0% of 18 control males. Cytologic examinations did not reveal malignant cells from the following materials: urines before and after prostatic massage or ejaculation, prostatic fluids and aspirates from epididymal cysts.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0024-7758
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
147-53
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:772199-Abnormalities, Drug-Induced,
pubmed-meshheading:772199-Adolescent,
pubmed-meshheading:772199-Cell Count,
pubmed-meshheading:772199-Clinical Trials as Topic,
pubmed-meshheading:772199-Cysts,
pubmed-meshheading:772199-Diethylstilbestrol,
pubmed-meshheading:772199-Epididymis,
pubmed-meshheading:772199-Female,
pubmed-meshheading:772199-Fetus,
pubmed-meshheading:772199-Genitalia, Male,
pubmed-meshheading:772199-Humans,
pubmed-meshheading:772199-Hypertrophy,
pubmed-meshheading:772199-Male,
pubmed-meshheading:772199-Pregnancy,
pubmed-meshheading:772199-Retrospective Studies,
pubmed-meshheading:772199-Semen,
pubmed-meshheading:772199-Spermatozoa,
pubmed-meshheading:772199-Testicular Diseases,
pubmed-meshheading:772199-Testis
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Structural and functional abnormalities in the sex organs of male offspring of mothers treated with diethylstilbestrol (DES).
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
|