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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-5-23
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pubmed:abstractText |
beta-Eudesmol, a sesquiterpenol present in Chinese herbs, improved the tetanic contraction impaired by diisopropylfluorophosphate in isolated mouse diaphragm preparations by an inhibition of the regenerative acetylcholine release. The antagonism was enhanced when a small concentration of obidoxime was present. Neither enzyme reactivation nor curare-like action was evident. beta-Eudesmol (300 mg/kg, i.p.) elevated the LD50 of diisopropylfluorophosphate (s.c.) in control mice from 4.2 to 6.4 mg/kg and in mice pretreated with atropine from 7.8 to 10.6 mg/kg. In mice pretreated with atropine and obidoxime, beta-eudesmol showed a greater synergistic effect, increasing the LD50 from 281 to more than 800 mg/kg. beta-Eudesmol also markedly alleviated diisopropylfluorophosphate-induced muscle fasciculation, tremor and convulsion and prolonged the time to death. It is proposed that beta-eudesmol may be added to the standard antidotal regimen (atropine plus obidoxime) for treating organophosphate intoxication.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Ulcer Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antidotes,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflurophate,
http://linkedlifedata.com/resource/pubmed/chemical/Neostigmine,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes, Eudesmane,
http://linkedlifedata.com/resource/pubmed/chemical/Terpenes,
http://linkedlifedata.com/resource/pubmed/chemical/beta-eudesmol
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
292
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
151-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7720787-Animals,
pubmed-meshheading:7720787-Anti-Ulcer Agents,
pubmed-meshheading:7720787-Antidotes,
pubmed-meshheading:7720787-Atropine,
pubmed-meshheading:7720787-Cholinesterase Inhibitors,
pubmed-meshheading:7720787-Electrophysiology,
pubmed-meshheading:7720787-Female,
pubmed-meshheading:7720787-Isoflurophate,
pubmed-meshheading:7720787-Lethal Dose 50,
pubmed-meshheading:7720787-Male,
pubmed-meshheading:7720787-Membrane Potentials,
pubmed-meshheading:7720787-Mice,
pubmed-meshheading:7720787-Mice, Inbred ICR,
pubmed-meshheading:7720787-Motor Endplate,
pubmed-meshheading:7720787-Muscle, Skeletal,
pubmed-meshheading:7720787-Muscle Contraction,
pubmed-meshheading:7720787-Neostigmine,
pubmed-meshheading:7720787-Organophosphorus Compounds,
pubmed-meshheading:7720787-Sesquiterpenes, Eudesmane,
pubmed-meshheading:7720787-Terpenes
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pubmed:year |
1995
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pubmed:articleTitle |
beta-Eudesmol as an antidote for intoxication from organophosphorus anticholinesterase agents.
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pubmed:affiliation |
Department of Pharmacology, College of Medicine, National Taiwan University, Taipei.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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