Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1995-5-24
pubmed:abstractText
In a previous paper on cyclodextrin-mediated capillary zone electrophoresis, it was shown that the use of short-chain tetraalkylammonium cations leads to a reversal in the direction of the electroosmotic flow without an adverse effect on enantioselectivity. As a result, enantiomeric resolution of basic (cationic) compounds can be improved as the electroosmotic flow counteracts the migration of solute enantiomers. It is demonstrated in this report that the scope of chiral separation of basic compounds can be further extended by a combination of reversing the electroosmotic flow and enhancing enantioselectivity through the chemical modifications of beta-cyclodextrin. Therefore, beta-cyclodextrin and its derivatives were evaluated as chiral recognition agents for the chiral separations of 22 basic compounds with rather complex molecular structures. The differences in enantioselectivity displayed by beta-cyclodextrin and derivatives are discussed in order to achieve a better understanding of the chiral interactions involved in the discrimination of solute enantiomers.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9673
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
692
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-65
pubmed:dateRevised
2009-1-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Extending the scope of chiral separation of basic compounds by cyclodextrin-mediated capillary zone electrophoresis.
pubmed:affiliation
Department of Chemistry, North Carolina State University, Raleigh 27695.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.