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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1995-5-25
|
| pubmed:abstractText |
The incidence of functional asplenia in sickle-hemoglobin C (SC) disease has not been defined, and the use of prophylactic penicillin to prevent life-threatening septicemia in this disorder is controversial. The percentage of red blood cells with pits (pit count) is a reliable assay of splenic function in other disorders but has not been validated in hemoglobin SC disease. To address these issues, we conducted a prospective, multicenter study of splenic function in persons with hemoglobin SC disease. Baseline clinical data were recorded, and red blood cell pit counts were performed on 201 subjects, aged 6 months to 90 years, with hemoglobin SC; 43 subjects underwent radionuclide liver-spleen scanning. Pit counts greater than 20% were associated with functional asplenia as assessed by liver-spleen scan, whereas pit counts less than 20% were found in subjects with preserved splenic function. Pit counts greater than 20% were present in 0 of 59 subjects (0%) less than 4 years of age, in 19 of 86 subjects (22%) 4 to 12 years of age, and in 25 of 56 subjects (45%) greater than 12 years of age. Other subjects with hemoglobin SC, who had previously undergone surgical splenectomy, had higher pit counts (59.7% +/- 9.5%) than splenectomized subjects without hemoglobinopathy (38.5% +/- 8.8%) or with sickle cell anemia (20.5% +/- 1.9%; P < .001). Two subjects with hemoglobin SC disease (not splenectomized), ages 14 and 15 years, with pit counts of 40.3% and 41.7% died from pneumococcal septicemia. These data indicate that functional asplenia occurs in many patients with hemoglobin SC disease, but its development is usually delayed until after 4 years of age. The pit count is a reliable measure of splenic function in hemoglobin SC disease, but values indicative of functional asplenia (> 20% in our laboratory) are higher than in other disorders. The routine administration of prophylactic penicillin to infants and young children with hemoglobin SC disease may not be necessary.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
85
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2238-44
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7718896-Adolescent,
pubmed-meshheading:7718896-Adult,
pubmed-meshheading:7718896-Aged,
pubmed-meshheading:7718896-Aged, 80 and over,
pubmed-meshheading:7718896-Altitude,
pubmed-meshheading:7718896-Anoxia,
pubmed-meshheading:7718896-Child,
pubmed-meshheading:7718896-Child, Preschool,
pubmed-meshheading:7718896-Colorado,
pubmed-meshheading:7718896-Disease Susceptibility,
pubmed-meshheading:7718896-Erythrocyte Count,
pubmed-meshheading:7718896-Erythrocytes, Abnormal,
pubmed-meshheading:7718896-Hemoglobin SC Disease,
pubmed-meshheading:7718896-Humans,
pubmed-meshheading:7718896-Infant,
pubmed-meshheading:7718896-Middle Aged,
pubmed-meshheading:7718896-Mononuclear Phagocyte System,
pubmed-meshheading:7718896-Prospective Studies,
pubmed-meshheading:7718896-Risk,
pubmed-meshheading:7718896-Sepsis,
pubmed-meshheading:7718896-Spleen,
pubmed-meshheading:7718896-Vacuoles
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Functional asplenia in hemoglobin SC disease.
|
| pubmed:affiliation |
Colorado Sickle Cell Treatment and Research Center, University of Colorado School of Medicine, Denver, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Multicenter Study
|