| pubmed-article:7717978 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7717978 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:7717978 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:7717978 | lifeskim:mentions | umls-concept:C1333707 | lld:lifeskim |
| pubmed-article:7717978 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:7717978 | lifeskim:mentions | umls-concept:C1155502 | lld:lifeskim |
| pubmed-article:7717978 | lifeskim:mentions | umls-concept:C0205132 | lld:lifeskim |
| pubmed-article:7717978 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7717978 | lifeskim:mentions | umls-concept:C0597876 | lld:lifeskim |
| pubmed-article:7717978 | pubmed:dateCreated | 1995-5-18 | lld:pubmed |
| pubmed-article:7717978 | pubmed:abstractText | Ligation of membrane immunoglobulin M (mIgM) receptor in the Ramos B-cell line induced tyrosine phosphorylation of several intracellular substrates, including the adaptor protein. Shc. Phosphorylated Shc could be seen to associate with Grb2 in a complex which included hSOS. Inasmuch as hSOS is involved in p21ras activation, we also demonstrated that mIgM ligation activated a Ras-dependent kinase cascade in which sequential activation of Raf-1 and MEK-1 culminates in the activation of p42 mitogen-activated protein (MAP) kinase (ERK-2). The tumour promoter and protein kinase C agonist, phorbol 12-myristate 13-acetate (PMA), also activated Raf-1, MEK-1, and MAP kinase in Ramos cells, but did not induce tyrosine phosphorylation of Shc or Shc/Grb2 association. Okadaic acid, another tumour promoter and serine/threonine phosphatase inhibitor, activated p42 MAP kinase without activating Raf-1 or MEK-1, suggesting the existence of a serine/threonine phosphatase which directly regulates MAP kinase activity. | lld:pubmed |
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| pubmed-article:7717978 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7717978 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7717978 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7717978 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7717978 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:7717978 | pubmed:author | pubmed-author:SuS CSC | lld:pubmed |
| pubmed-article:7717978 | pubmed:author | pubmed-author:GuptaSS | lld:pubmed |
| pubmed-article:7717978 | pubmed:author | pubmed-author:WangSS | lld:pubmed |
| pubmed-article:7717978 | pubmed:author | pubmed-author:KumarGG | lld:pubmed |
| pubmed-article:7717978 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7717978 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7717978 | pubmed:volume | 307 ( Pt 1) | lld:pubmed |
| pubmed-article:7717978 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7717978 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7717978 | pubmed:pagination | 215-23 | lld:pubmed |
