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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-5-12
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pubmed:abstractText |
Proteasomes (prosomes) are large multiprotein complexes. They are involved in protein degradation of ubiquitin-conjugated proteins and in the generation of MHC class I peptides. We gave further evidence that they interfere with in vitro protein synthesis. Proteasomes inhibit the translation of Tobacco mosaic virus RNA. Analysis of cell-free systems by sucrose gradient centrifugation revealed that they prevent the formation of 80S initiation complexes but not the early phase of initiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-4851
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7715610-Animals,
pubmed-meshheading:7715610-Cattle,
pubmed-meshheading:7715610-Cell-Free System,
pubmed-meshheading:7715610-Cysteine Endopeptidases,
pubmed-meshheading:7715610-Kinetics,
pubmed-meshheading:7715610-Liver,
pubmed-meshheading:7715610-Multienzyme Complexes,
pubmed-meshheading:7715610-Peptide Chain Initiation, Translational,
pubmed-meshheading:7715610-Proteasome Endopeptidase Complex,
pubmed-meshheading:7715610-Protein Biosynthesis,
pubmed-meshheading:7715610-RNA, Transfer, Met,
pubmed-meshheading:7715610-RNA, Viral,
pubmed-meshheading:7715610-Ribosomes,
pubmed-meshheading:7715610-Tobacco Mosaic Virus
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pubmed:year |
1994
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pubmed:articleTitle |
Proteasomes (prosomes) inhibit the translation of tobacco mosaic virus RNA by preventing the formation of initiation complexes.
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pubmed:affiliation |
Biologisches Institut University of Stuttgart, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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