Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1995-5-18
|
| pubmed:abstractText |
Pulmonary edema following smoke inhalation is due to the chemical toxins in smoke and not to the heat. We have shown that acrolein, a common component of smoke, induces pulmonary edema, perhaps via release of leukotrienes. We, therefore, hypothesized that acrolein, a component of smoke from burning cotton, might have a major role in producing pulmonary edema in sheep after cotton smoke inhalation and that BW-755C, a combined cyclo- and lipoxygenase inhibitor, would prevent the edema, whereas indomethacin, a cyclooxygenase inhibitor, would not. In control anesthetized sheep (n = 7), 128 breaths of cotton smoke induced no change in pulmonary arterial pressure but induced increases (P < 0.05) in pulmonary lymph flow from 4.4 +/- 0.8 (SE) to 15 +/- 2.7 ml/h, lymph protein flux from 0.25 +/- 0.08 to 0.80 +/- 0.16 g/h, and blood-corrected wet-to-dry weight ratios from a normal value of 3.8 +/- 0.07 (n = 9) to 4.5 +/- 0.18. Indomethacin (n = 6) did not significantly prevent these changes, whereas BW-755C decreased lung lymph flow change from 5 +/- 1 to 7 +/- 2 ml/h (P = NS), lymph protein flux from 0.25 +/- 0.08 to 0.35 +/- 0.1 g/h (P = NS), and weight-to-dry ratio from normal to 3.9 +/- 2.1 (P = NS). These data suggest leukotrienes may have a role in producing cotton smoke-induced noncardiogenic pulmonary edema.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
8750-7587
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
78
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
64-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7713845-4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine,
pubmed-meshheading:7713845-Animals,
pubmed-meshheading:7713845-Blood Pressure,
pubmed-meshheading:7713845-Body Fluids,
pubmed-meshheading:7713845-Cardiac Output,
pubmed-meshheading:7713845-Eicosanoids,
pubmed-meshheading:7713845-Gossypium,
pubmed-meshheading:7713845-Indomethacin,
pubmed-meshheading:7713845-Pulmonary Circulation,
pubmed-meshheading:7713845-Pulmonary Edema,
pubmed-meshheading:7713845-Pulmonary Wedge Pressure,
pubmed-meshheading:7713845-Sheep,
pubmed-meshheading:7713845-Smoke Inhalation Injury,
pubmed-meshheading:7713845-Vascular Resistance
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
BW-755C diminishes smoke-induced pulmonary edema.
|
| pubmed:affiliation |
Department of Medicine, Massachusetts General Hospital, Shriners Burn Institute, Boston.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|