Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-5-18
|
| pubmed:databankReference | |
| pubmed:abstractText |
Two human clathrin light-chain genes have been defined. The gene (CLTA) encoding the LCa light chain maps to the long arm of chromosome 12 at 12q23-q24 and that encoding the LCb light chain (CLTB) maps to the long arm of chromosome 4 at 4q2-q3. Isolation and characterization of partial genomic clones encoding human LCa and LCb reveal the neuron-specific insertions of the LCa and LCb proteins to be encoded by discrete exons, thus proving that clathrin light chains undergo alternate mRNA splicing to generate tissue-specific protein isoforms. The insertion sequence of LCb is encoded by a single exon and that of LCa by two exons. The first of the two neuron-specific LCa exons is homologous to the corresponding LCb exon. An intronic sequence of the LCb gene with similarity to the second neuron-specific exon of the LCa gene has been identified.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0888-7543
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
24
|
| pubmed:geneSymbol |
CLTA,
CLTB
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
440-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7713494-Animals,
pubmed-meshheading:7713494-Base Sequence,
pubmed-meshheading:7713494-Chromosome Mapping,
pubmed-meshheading:7713494-Chromosomes, Human, Pair 12,
pubmed-meshheading:7713494-Chromosomes, Human, Pair 4,
pubmed-meshheading:7713494-Clathrin,
pubmed-meshheading:7713494-Cloning, Molecular,
pubmed-meshheading:7713494-Consensus Sequence,
pubmed-meshheading:7713494-DNA,
pubmed-meshheading:7713494-DNA, Complementary,
pubmed-meshheading:7713494-Exons,
pubmed-meshheading:7713494-Humans,
pubmed-meshheading:7713494-Hybrid Cells,
pubmed-meshheading:7713494-In Situ Hybridization,
pubmed-meshheading:7713494-Mice,
pubmed-meshheading:7713494-Molecular Sequence Data,
pubmed-meshheading:7713494-Neurons,
pubmed-meshheading:7713494-RNA Splicing,
pubmed-meshheading:7713494-Repetitive Sequences, Nucleic Acid
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Chromosomal location and some structural features of human clathrin light-chain genes (CLTA and CLTB).
|
| pubmed:affiliation |
Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|