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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1995-5-18
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pubmed:databankReference |
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pubmed:abstractText |
The inbred mouse strain, C57BL/6J, was derived from mice of the Mus musculus complex. C57BL/6J can be crossed in the laboratory with a closely related mouse species, M. spretus to produce fertile offspring; however there has been no previous evidence of gene flow between M. spretus and M. musculus in nature. Analysis of the repetitive sequence LINE-1, using both direct sequence analysis and genomic Southern blot hybridization to species-specific LINE-1 hybridization probes, demonstrates the presence of LINE-1 elements in C57BL/6J that were derived from the species M. spretus. These spretus-like LINE-1 elements in C57BL/6J reveal a cross to M. spretus somewhere in the history of C57BL/6J. It is unclear if the spretus-like LINE-1 elements are still embedded in flanking DNA derived from M. spretus or if they have transposed to new sites. The number of spretus-like elements detected suggests a maximum of 6.5% of the C57BL/6J genome may be derived from M. spretus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-1783397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-2056531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-2829228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-2879770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-3023821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-3472735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-6315529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-6375655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-678291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-720505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-7254315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-8064855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-8070666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-8105360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7713440-8449493
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
901-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7713440-Animals,
pubmed-meshheading:7713440-Base Sequence,
pubmed-meshheading:7713440-Biological Evolution,
pubmed-meshheading:7713440-Blotting, Southern,
pubmed-meshheading:7713440-Crosses, Genetic,
pubmed-meshheading:7713440-DNA Probes,
pubmed-meshheading:7713440-Mice,
pubmed-meshheading:7713440-Mice, Inbred C57BL,
pubmed-meshheading:7713440-Molecular Sequence Data,
pubmed-meshheading:7713440-Muridae,
pubmed-meshheading:7713440-Phylogeny,
pubmed-meshheading:7713440-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7713440-Sequence Analysis, DNA
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pubmed:year |
1995
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pubmed:articleTitle |
Mus spretus LINE-1 sequences detected in the Mus musculus inbred strain C57BL/6J using LINE-1 DNA probes.
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pubmed:affiliation |
Department of Biochemistry, University of Texas Health Science Center at San Antonio 78284-7760, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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