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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-5-18
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pubmed:abstractText |
1. In the isolated rabbit arteries, the effects of intravenous cyclosporin A preparation (Sandimmun) and its solvent (Cremophor-EL) on acetylcholine-induced endothelium-dependent relaxation were investigated in the absence and presence of indomethacin (10(-5) M), a cyclooxygenase inhibitor. 2. The effect of indomethacin on the drug- and solvent-induced contraction of superior mesenteric artery was also evaluated. 3. The inhibitory effects of cyclosporin and the solvent on endothelium-dependent relaxations were decreased by indomethacin. The direct contractions produced by the drug and the solvent in rabbit mesenteric artery were inhibited by indomethacin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0306-3623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
93-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:7713371-Acetylcholine,
pubmed-meshheading:7713371-Animals,
pubmed-meshheading:7713371-Cyclosporine,
pubmed-meshheading:7713371-Endothelium, Vascular,
pubmed-meshheading:7713371-Glycerol,
pubmed-meshheading:7713371-Indomethacin,
pubmed-meshheading:7713371-Male,
pubmed-meshheading:7713371-Pharmaceutical Vehicles,
pubmed-meshheading:7713371-Rabbits,
pubmed-meshheading:7713371-Vasoconstriction,
pubmed-meshheading:7713371-Vasodilation
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pubmed:year |
1995
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pubmed:articleTitle |
The effect of indomethacin on cyclosporin A- and its solvent-induced inhibition of endothelium-dependent relaxation and the drug-induced contraction of rabbit isolated arteries.
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pubmed:affiliation |
Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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