Linked Life Data

7712884

Source:http://linkedlifedata.com/resource/pubmed/id/7712884

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1995-5-16
pubmed:abstractText
Fourty cases with pregnancy induced hypertension (PIH) and 100 normal pregnant women were selected for this study. The distribution of histo-compatibility antigen D region (HLA-DR) frequency, the frequency of homozygosity and the HLA-DR antigens sharing between partners were investigated. The results showed that the frequency of HLA-DR4 was significantly higher in PIH than that in normal pregnancy (P < 0.001). There was a very high DR antigen sharing between partners in PIH as compared to normal pregnancy (P < 0.01), specially obvious in the frequency of DR4 antigen sharing in PIH (P < 0.0001). There was, however, no significant difference in the frequency of homozygosity or heterozygosity between HLA-DR and DR4 locus. This study suggested that HLA-DR4 may be related to the genetic susceptibility of PIH. This correlation is presumably due to a linkage imbalance of susceptible gene of PIH and DR4, but whether DR4 acts directly as an immunodeficient gene remains to be determined.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0529-567X
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
654-6, 698
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[Relation between histo-compatibility antigen immunogenetics and pregnancy induced hypertension].
pubmed:affiliation
Obstet and Gynecol Hospital, Shanghai Medical University.
pubmed:publicationType
Journal Article, English Abstract