Linked Life Data

7712690

Source:http://linkedlifedata.com/resource/pubmed/id/7712690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-17
pubmed:abstractText
The influence of hypoxaemia on anaerobic energy production during arm exercise (AE) has been investigated. Six men were studied during maximal AE and during 10 min of sitting submaximal AE under both normoxic (AEN) and hypoxic (AEH, respiratory hypoxia, 12% O2) conditions. Peak pulmonary oxygen uptake (VO2) during maximal AE in normoxia and hypoxia was 2.25 +/- 0.15 and 2.18 +/- 0.14 l min-1, respectively (P < 0.05). The absolute workload was the same during submaximal AEN and AEH and corresponded to 54% of peak VO2 during normoxic maximal AE. To eliminate the potential influence of differences in catecholamine levels on the metabolic response, the submaximal experiments were performed during beta-adrenoceptor blockade. Oxygen deficit was 1.45 +/- 0.26 and 1.67 +/- 0.191 during AEN and AEH, respectively (n.s.). Oxygen extraction at steady state was lower during AEH than during AEN, and assuming a similar O2 demand this corresponds to a 14% higher muscle blood flow during AEH. At the onset of both AEN and AEH, O2 extraction (a-v O2) across the arm increased transiently above that at steady state, the increase being more pronounced during AEN than during AEH (P < 0.05). Muscle oxygenation, measured by near-infrared spectroscopy, demonstrated an initial decrease which was partially reversed as exercise proceeded. The reversal of muscle O2 desaturation was slower in all subjects during AEH (t1/2 = 2.4 +/- 0.2 min) than during AEN (t1/2 = 1.2 +/- 0.2 min; P < 0.01). After 10 min of exercise, arterial blood lactate was higher (P < 0.05) during AEH (5.5 +/- 0.2 mmol l-1) than during AEN (4.9 +/- 0.6 mmol l-1), whereas arterial plasma ammonia (NH3) was similar. The arteriovenous difference for both lactate and ammonia was similar during AEN and AEH. It is concluded that the high anaerobic energy production at the onset of AE is associated with a transient increase in O2 extraction and a transient decrease in muscle oxygenation. The effects of hypoxaemia on peak VO2, oxygen deficit and blood metabolites are less pronounced than previously described during submaximal leg exercise (LE).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0144-5979
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-37
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Effect of hypoxia on muscle oxygenation and metabolism during arm exercise in humans.
pubmed:affiliation
Department of Clinical Physiology, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't