Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1995-5-15
|
| pubmed:abstractText |
We have analyzed by Southern blotting the ALL-1 (MLL, HRX, Hrtx 1) gene configuration in a series of 126 patients with acute myeloid leukemia (AML) representative of all ages and French-American-British Classification groups and correlated this genetic feature with clinical and biological features at diagnosis. ALL-1 gene rearrangements were detected in 17 of the 74 cases with M4-M5 (myelomonocytic and monocytic) AML and in 2 of the 52 cases with other leukemic subtypes (P < 0.01). Within the series of 74 M4-M5 patients, ALL-1 rearrangements were significantly associated with French-American-British Classification M5 (P = 0.009), high WBC (P = 0.002), and young age. In particular, all 5 infant (< 1.5 years) AML cases, 6 of the 19 (31%) patients between 1.5 and 18 years of age, and 6 of the 50 (12%) patients > 18 years old showed an altered ALL-1 genomic configuration (P < 0.001). Immunophenotypic characterization revealed coexpression of lymphoid and myeloid markers in 6 of 17 ALL-1 rearranged M4-M5 cases. The IgH gene configuration was studied in 77 of 126 AMLs. Five patients (6%) showed IgH clonal rearrangements and all were in the ALL-1 rearranged group (P < 0.0001). Our findings indicate that ALL-1 rearrangement is the commonest genetic alteration presently detectable in M4-M5 AML, particularly in childhood where it is found in up to one-third of all cases. The association of IgH rearrangements with ALL-1 alterations in AML, coupled to the frequent detection in this subset of lymphoid associated markers, further supports the origin of these tumors from a common multipotent precursor with bipotential lymphoid and monocytic differentiation capability.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloid-Lymphoid Leukemia Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
55
|
| pubmed:geneSymbol |
ALL-1,
HRX,
Hrts 1,
MLL
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
1625-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7712464-Adolescent,
pubmed-meshheading:7712464-Adult,
pubmed-meshheading:7712464-Age Factors,
pubmed-meshheading:7712464-Aged,
pubmed-meshheading:7712464-Child,
pubmed-meshheading:7712464-Child, Preschool,
pubmed-meshheading:7712464-DNA-Binding Proteins,
pubmed-meshheading:7712464-Female,
pubmed-meshheading:7712464-France,
pubmed-meshheading:7712464-Gene Rearrangement,
pubmed-meshheading:7712464-Great Britain,
pubmed-meshheading:7712464-Humans,
pubmed-meshheading:7712464-Immunophenotyping,
pubmed-meshheading:7712464-Infant,
pubmed-meshheading:7712464-Infant, Newborn,
pubmed-meshheading:7712464-Leukemia, Monocytic, Acute,
pubmed-meshheading:7712464-Leukemia, Myelomonocytic, Acute,
pubmed-meshheading:7712464-Male,
pubmed-meshheading:7712464-Middle Aged,
pubmed-meshheading:7712464-Myeloid-Lymphoid Leukemia Protein,
pubmed-meshheading:7712464-Proto-Oncogenes,
pubmed-meshheading:7712464-Restriction Mapping,
pubmed-meshheading:7712464-Transcription Factors,
pubmed-meshheading:7712464-United States,
pubmed-meshheading:7712464-Zinc Fingers
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age.
|
| pubmed:affiliation |
Dipartimento di Biopatologia Umana, University La Sapienza, Rome, Italy.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|