Linked Life Data

7712236

Source:http://linkedlifedata.com/resource/pubmed/id/7712236

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-18
pubmed:abstractText
White matter disease is a relatively common neuropathological change observed in the central nervous system (CNS) tissues of patients with AIDS at autopsy. This disease ranges from small foci of myelin loss to extensive areas of demyelination. In the studies reported here, four of six unselected adult patients with AIDS had areas of demyelination in their CNS tissues at the time of their deaths. In the tissues examined, the severity of the demyelinative disease varied among the patients from a single focus of demyelination to essentially confluent loss of myelin in subcortical white matter and other CNS structures. The demyelinative disease in the brains of these patients was closely associated with active HHV-6 infection. The infected cells were present only in areas of demyelination, and they were never observed in tissue areas free of pathological changes. The HHV-6-associated neuropathology observed in the brains of these patients was identical to that described in an adult bone marrow transplant (BMT) patient with fatal HHV-6 encephalitis. Thus HHV-6-induced white matter disease appears to be a distinct pathological syndrome. Pathogenic mechanisms involved in this disease are unknown. However, the existence of HHV-6 leukoencephalopathy in a BMT patient demonstrates the potential for HHV-6 leukoencephalopathy in a BMT patient demonstrates the potential for HHV-6 to cause this syndrome without need for a cofactor or copathogen such as HIV.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1077-9450
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-73
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Active human herpesvirus (HHV-6) infection of the central nervous system in patients with AIDS.
pubmed:affiliation
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA.
pubmed:publicationType
Journal Article