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rdf:type |
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lifeskim:mentions |
umls-concept:C0006675,
umls-concept:C0030685,
umls-concept:C0205145,
umls-concept:C0376604,
umls-concept:C0391871,
umls-concept:C0521428,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1550548,
umls-concept:C1555714,
umls-concept:C1705654,
umls-concept:C1963578
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pubmed:issue |
7
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pubmed:dateCreated |
1995-5-11
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pubmed:abstractText |
"Snapshot" images of localized Ca2+ influx into patch-clamped chromaffin cells were captured by using a recently developed pulsed-laser imaging system. Transient opening of voltage-sensitive Ca2+ channels gave rise to localized elevations of Ca2+ that had the appearance of either "hotspots" or partial rings found immediately beneath the plasma membrane. When the Ca2+ imaging technique was employed in conjunction with flame-etched carbon-fiber electrodes to spatially map the release sites of catecholamines, it was observed that the sites of Ca2+ entry and catecholamine release were colocalized. These results provide functional support for the idea that secretion occurs from "active zone"-like structures in neuroendocrine cells.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1321498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1326297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1331424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1350109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1538782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1649638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1682815,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1944573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1952084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-1961743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-2447647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-2560556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-2611329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-2653866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-2768340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-2769434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-3169247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-3395658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-4995202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-6273920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-6643581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-6894887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-6959149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-7832825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-7906056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-7909233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-7919929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-7931329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-7948669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-8006030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-8052623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-8096639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-8107778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-8310297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-8325848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-8412305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7708668-8505984
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2474-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7708668-Adrenal Medulla,
pubmed-meshheading:7708668-Animals,
pubmed-meshheading:7708668-Biological Transport,
pubmed-meshheading:7708668-Calcium,
pubmed-meshheading:7708668-Catecholamines,
pubmed-meshheading:7708668-Cattle,
pubmed-meshheading:7708668-Cell Membrane,
pubmed-meshheading:7708668-Cells, Cultured,
pubmed-meshheading:7708668-Electrophysiology,
pubmed-meshheading:7708668-Exocytosis,
pubmed-meshheading:7708668-Spectrometry, Fluorescence
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pubmed:year |
1995
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pubmed:articleTitle |
Colocalization of calcium entry and exocytotic release sites in adrenal chromaffin cells.
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pubmed:affiliation |
Department of Physiology and Biophysics, Mayo Clinic, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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