|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009015,
umls-concept:C0009219,
umls-concept:C0017262,
umls-concept:C0035696,
umls-concept:C0086418,
umls-concept:C0162801,
umls-concept:C0185117,
umls-concept:C0330390,
umls-concept:C0376315,
umls-concept:C0597357,
umls-concept:C1711351,
umls-concept:C2911684
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|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1995-5-10
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|
pubmed:databankReference |
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|
pubmed:abstractText |
Two forms of cDNA coding for the human GABAA beta 2 subunit have been cloned and sequenced. The two sequences differ by a 114 base pair insertion. The insert contains a phosphorylation consensus sequence for calmodulin-dependent protein kinase II. Quantitative PCR studies show that h beta 2L cDNA represents 10-15% of total h beta 2 cDNA in the 10 brain substructures tested. Analysis of human genomic southern blots suggests that the two forms might arise by differential splicing.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
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pubmed:month |
Jan
|
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pubmed:issn |
0169-328X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7707873-Blotting, Northern,
pubmed-meshheading:7707873-Blotting, Southern,
pubmed-meshheading:7707873-Brain,
pubmed-meshheading:7707873-Cloning, Molecular,
pubmed-meshheading:7707873-DNA, Complementary,
pubmed-meshheading:7707873-Gene Expression,
pubmed-meshheading:7707873-Humans,
pubmed-meshheading:7707873-Molecular Sequence Data,
pubmed-meshheading:7707873-Polymerase Chain Reaction,
pubmed-meshheading:7707873-RNA, Messenger,
pubmed-meshheading:7707873-Receptors, GABA-A,
pubmed-meshheading:7707873-Sequence Analysis,
pubmed-meshheading:7707873-Sequence Homology, Amino Acid
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|
pubmed:year |
1995
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pubmed:articleTitle |
Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor.
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pubmed:affiliation |
Upjohn Company, Kalamazoo, MI 49001.
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pubmed:publicationType |
Journal Article
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