| pubmed-article:7706739 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7706739 | lifeskim:mentions | umls-concept:C0030664 | lld:lifeskim |
| pubmed-article:7706739 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:7706739 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:7706739 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:7706739 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:7706739 | pubmed:dateCreated | 1995-5-11 | lld:pubmed |
| pubmed-article:7706739 | pubmed:abstractText | To assess the role of IFN-gamma in the in vivo regulation of Th subset differentiation by IL-12, schistosome egg-induced Th2 responses and granuloma formation were studied in IFN-gamma knock-out (gamma KO) mice in which the absence of endogenous IFN-gamma is assured. Rather than suppressing pathology and eosinophilia as observed in wild-type animals, exogenous IL-12 in egg-injected gamma KO mice exacerbated Th2-dependent granuloma formation while failing to reduce peak tissue eosinophilia. Similarly, instead of inhibiting its production, IL-12 caused a dramatic increase in serum IgE levels in gamma KO animals after egg injection. Although the suppressive effects of IL-12 on Th2 responses were blocked in the absence of IFN-gamma, lymphocyte proliferation and IL-2 production were enhanced, a phenomenon which may underlie the observed exacerbation of egg-induced pathology. These findings formally establish that IL-12 inhibits Th2 development indirectly in vivo through the stimulation of IFN-gamma synthesis. In contrast, its promotion of Th1-associated responses seems to be at least partly a result of the direct action of the cytokine. | lld:pubmed |
| pubmed-article:7706739 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7706739 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7706739 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7706739 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7706739 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7706739 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7706739 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7706739 | pubmed:author | pubmed-author:SherAA | lld:pubmed |
| pubmed-article:7706739 | pubmed:author | pubmed-author:CheeverA WAW | lld:pubmed |
| pubmed-article:7706739 | pubmed:author | pubmed-author:WynnT ATA | lld:pubmed |
| pubmed-article:7706739 | pubmed:author | pubmed-author:HienySS | lld:pubmed |
| pubmed-article:7706739 | pubmed:author | pubmed-author:JankovicDD | lld:pubmed |
| pubmed-article:7706739 | pubmed:author | pubmed-author:JardieuPP | lld:pubmed |
| pubmed-article:7706739 | pubmed:author | pubmed-author:ZioncheckKK | lld:pubmed |
| pubmed-article:7706739 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7706739 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7706739 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:7706739 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7706739 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7706739 | pubmed:pagination | 3999-4009 | lld:pubmed |
| pubmed-article:7706739 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7706739 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7706739 | pubmed:articleTitle | IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma. | lld:pubmed |
| pubmed-article:7706739 | pubmed:affiliation | Host-Parasite Relations Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:7706739 | pubmed:publicationType | Journal Article | lld:pubmed |
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