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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1995-5-11
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pubmed:abstractText |
To assess the role of IFN-gamma in the in vivo regulation of Th subset differentiation by IL-12, schistosome egg-induced Th2 responses and granuloma formation were studied in IFN-gamma knock-out (gamma KO) mice in which the absence of endogenous IFN-gamma is assured. Rather than suppressing pathology and eosinophilia as observed in wild-type animals, exogenous IL-12 in egg-injected gamma KO mice exacerbated Th2-dependent granuloma formation while failing to reduce peak tissue eosinophilia. Similarly, instead of inhibiting its production, IL-12 caused a dramatic increase in serum IgE levels in gamma KO animals after egg injection. Although the suppressive effects of IL-12 on Th2 responses were blocked in the absence of IFN-gamma, lymphocyte proliferation and IL-2 production were enhanced, a phenomenon which may underlie the observed exacerbation of egg-induced pathology. These findings formally establish that IL-12 inhibits Th2 development indirectly in vivo through the stimulation of IFN-gamma synthesis. In contrast, its promotion of Th1-associated responses seems to be at least partly a result of the direct action of the cytokine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3999-4009
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7706739-Animals,
pubmed-meshheading:7706739-Antigens, Helminth,
pubmed-meshheading:7706739-Cytokines,
pubmed-meshheading:7706739-Eosinophils,
pubmed-meshheading:7706739-Female,
pubmed-meshheading:7706739-Gene Expression,
pubmed-meshheading:7706739-Granuloma,
pubmed-meshheading:7706739-Immunoglobulin E,
pubmed-meshheading:7706739-Interferon-gamma,
pubmed-meshheading:7706739-Interleukin-12,
pubmed-meshheading:7706739-Lung,
pubmed-meshheading:7706739-Lymphocyte Activation,
pubmed-meshheading:7706739-Mice,
pubmed-meshheading:7706739-Mice, Inbred C57BL,
pubmed-meshheading:7706739-Mice, Knockout,
pubmed-meshheading:7706739-Ovum,
pubmed-meshheading:7706739-RNA, Messenger,
pubmed-meshheading:7706739-Recombinant Proteins,
pubmed-meshheading:7706739-Schistosoma mansoni,
pubmed-meshheading:7706739-Schistosomiasis mansoni,
pubmed-meshheading:7706739-Th1 Cells,
pubmed-meshheading:7706739-Th2 Cells
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pubmed:year |
1995
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pubmed:articleTitle |
IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-gamma.
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pubmed:affiliation |
Host-Parasite Relations Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article
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