Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-5-9
pubmed:abstractText
The contribution to systemic lupus erythematosus (SLE) of three lupus-associated polymorphisms (involving the C4A2 complement component, Humhv3005 and the T cell antigen receptor alpha chain gene) are investigated in 81 individuals from 14 multiplex SLE families, 41 unrelated lupus patients, and 88 unrelated healthy controls. The results show a strong association between C4A deletion and SLE in these families. While the current study confirms the previously reported association between hv3005 deletion and sporadic SLE, the study fails to support this association in familial SLE patients. Moreover, no correlation is detected between the occurrence of hv3005 deletion and C4A null alleles in lupus patients, suggesting that the effects of these genetic polymorphisms on predisposition to lupus are independent. The previously reported lupus-associated T cell receptor (TCR) alpha chain polymorphism is not detected in any of the individuals studied here. The combined data suggest that C4A null alleles predispose strongly to development of lupus, whereas the influence of hv3005 deletion is relatively weak. The results also suggest that contributions of weak susceptibility genes such as hv3005 to disease predisposition may be obscured by the effects of stronger genetic factors and thus need to be examined in patients lacking these factors.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1331240, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1334971, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1438230, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1500714, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1605907, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1676037, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1751307, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1839881, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1971731, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-1979334, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2117273, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2122448, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2130120, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2130121, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2170450, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2217961, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2320951, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2439101, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2469441, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2509520, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2538551, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2676849, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-2993909, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-3014041, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-3137675, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-3263866, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-3396540, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-3499152, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-3823889, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-7138600, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-8136008, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-8233786, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-8293460, http://linkedlifedata.com/resource/pubmed/commentcorrection/7706484-8490662
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1766-72
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:7706484-Base Sequence, pubmed-meshheading:7706484-Canada, pubmed-meshheading:7706484-Complement C4a, pubmed-meshheading:7706484-European Continental Ancestry Group, pubmed-meshheading:7706484-Female, pubmed-meshheading:7706484-Gene Deletion, pubmed-meshheading:7706484-Genetics, Population, pubmed-meshheading:7706484-Genome, Human, pubmed-meshheading:7706484-Humans, pubmed-meshheading:7706484-Immunoglobulin Variable Region, pubmed-meshheading:7706484-Lupus Erythematosus, Systemic, pubmed-meshheading:7706484-Male, pubmed-meshheading:7706484-Molecular Sequence Data, pubmed-meshheading:7706484-Pedigree, pubmed-meshheading:7706484-Polymorphism, Restriction Fragment Length, pubmed-meshheading:7706484-Receptors, Antigen, T-Cell, alpha-beta, pubmed-meshheading:7706484-Risk Factors, pubmed-meshheading:7706484-United States
pubmed:year
1995
pubmed:articleTitle
Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus.
pubmed:affiliation
Department of Medicine, University of California, San Diego, La Jolla 92093-0663, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't