Linked Life Data

7703398

Source:http://linkedlifedata.com/resource/pubmed/id/7703398

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-5-9
pubmed:abstractText
Several isoforms of the NMDA receptor 1 (NR1) subunits of the ionotropic NMDA (N-methyl-D-aspartate) glutamate receptor contain a consensus site for phosphorylation by protein kinase C (PKC) which, once phosphorylated results in an increased conductance through the receptor channel. Using in situ hybridization, we investigated the expression of NR1 subunits sensitive or insensitive to modification by PKC in the granule cells of the dentate gyrus of the hippocampus, following the induction of long-term potentiation (LTP). A selective 50% increase only in the levels of mRNA NR1 subunits containing this consensus sequence for PKC phosphorylation was seen 48 h after LTP induction. The change in the expression of PKC-sensitive NR1 subunits may be the molecular basis for the increased response of the post-synaptic cell to released glutamate during the maintenance phase of LTP.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
119-23
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Regulation of the expression of NR1 NMDA glutamate receptor subunits during hippocampal LTP.
pubmed:affiliation
Neurobiology Division, Medical Research Council Centre, Cambridge, UK.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't