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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10-11
|
| pubmed:dateCreated |
1995-5-10
|
| pubmed:abstractText |
Platelet functionality alterations have been correlated to the onset of hypertension in pregnancy and oral Mg++ supplementation has been clinically postulated to counteract such alterations. We, therefore tested the effect of 4 weeks oral Mg++ pyrrolidone carboxylate supplementation on platelet function. Forty-eight pregnant women were enrolled in the study at the beginning of the third trimester (30-32 weeks). Twenty women were preeclamptic, while 28 remained normotensive and served as controls. All the women received 360 mg/day magnesium pyrrolidone carboxylate for 4 weeks. DPH fluorescence, Na+/K(+)-ATPase and Ca(++)-ATPase activity, intracellular free Ca++ concentrations were determined prior and after the 4-weeks supplementation. Oral Mg++ supplementation significantly increased platelet DPH fluorescence in both normotensive and preeclamptic women. In normotensive pregnant women, it also significantly increased the activity of Na+/K(+)-ATPase, the activity of Ca(++)-ATPase and reduced the concentration of intraplatelet free Ca++. In hypertensive pregnant women, Mg supplementation increases Na+/K(+)-ATPase activity and decreases intracellular free Ca++; this, in turn, contributes to reducing the activity of Ca(++)-ATPase. Magnesium supplementation to preventing hypertension in pregnancy seems to have a consistent biochemical and clinical background.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0037-8771
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
70
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
249-56
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:7702828-Administration, Oral,
pubmed-meshheading:7702828-Blood Platelets,
pubmed-meshheading:7702828-Calcium-Transporting ATPases,
pubmed-meshheading:7702828-Female,
pubmed-meshheading:7702828-Humans,
pubmed-meshheading:7702828-Hypertension,
pubmed-meshheading:7702828-Magnesium,
pubmed-meshheading:7702828-Pregnancy,
pubmed-meshheading:7702828-Pregnancy Complications, Cardiovascular,
pubmed-meshheading:7702828-Sodium-Potassium-Exchanging ATPase
|
| pubmed:articleTitle |
Functional platelet modifications induced by oral magnesium supplementation in normotensive and hypertensive pregnancy.
|
| pubmed:affiliation |
Institute of Gynecology and Obstetrics, University of Ancona.
|
| pubmed:publicationType |
Journal Article
|