| pubmed-article:7700889 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7700889 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:7700889 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7700889 | lifeskim:mentions | umls-concept:C0678879 | lld:lifeskim |
| pubmed-article:7700889 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:7700889 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7700889 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7700889 | pubmed:dateCreated | 1995-4-28 | lld:pubmed |
| pubmed-article:7700889 | pubmed:abstractText | Effects of cyclosporine (CyA) on ovarian function and the possible role of prolactin in mediating these effects were examined in young female rats. The animals were sham-operated or rendered hyperprolactinemic by transplanting pituitary glands under the renal capsule. Cyclosporine prevented the increase in plasma prolactin levels in grafted rats. However, in sham-operated animals plasma prolactin levels were increased after 8 days of CyA treatment. Plasma levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were reduced 8 days after pituitary grafting and increased by CyA at both Day 2 and Day 8 of treatment. The content of LHRH in the hypothalamus was not affected on Day 2 but was reduced on Day 8 after grafting on CyA therapy. Plasma estradiol levels were increased by CyA in sham-operated rats on Day 2 and 8 of treatment, and in pituitary-grafted rats on Day 8 of therapy. In sham-operated rats, ovarian estradiol content was reduced after 2 and after 8 days of CyA administration. In pituitary-grafted rats, the ovarian estradiol content was suppressed after 8 days, and CyA treatment prevented this effect. Ovarian estradiol release in vitro under basal conditions was greater in ovaries derived from 38-day-old than in those from 32-day-old animals. The ovarian estradiol response to human chorionic gonadotropin (hCG) in vitro was increased 2 days after pituitary transplantation. Administration of CyA for 8 days increased basal and hCG-stimulated estradiol release in both sham-operated and pituitary-grafted animals. The present findings suggest that CyA can alter ovarian function by acting directly at the gonadal level. However, a hypothalamic-hypophyseal site of action cannot be ruled out. | lld:pubmed |
| pubmed-article:7700889 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7700889 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7700889 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7700889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7700889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7700889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7700889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7700889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7700889 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7700889 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7700889 | pubmed:issn | 0037-9727 | lld:pubmed |
| pubmed-article:7700889 | pubmed:author | pubmed-author:MorenoM LML | lld:pubmed |
| pubmed-article:7700889 | pubmed:author | pubmed-author:EsquifinoA... | lld:pubmed |
| pubmed-article:7700889 | pubmed:author | pubmed-author:VillanúaM AMA | lld:pubmed |
| pubmed-article:7700889 | pubmed:author | pubmed-author:AgrasalCC | lld:pubmed |
| pubmed-article:7700889 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7700889 | pubmed:volume | 208 | lld:pubmed |
| pubmed-article:7700889 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7700889 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7700889 | pubmed:pagination | 397-403 | lld:pubmed |
| pubmed-article:7700889 | pubmed:dateRevised | 2007-11-2 | lld:pubmed |
| pubmed-article:7700889 | pubmed:meshHeading | pubmed-meshheading:7700889-... | lld:pubmed |
| pubmed-article:7700889 | pubmed:meshHeading | pubmed-meshheading:7700889-... | lld:pubmed |
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| pubmed-article:7700889 | pubmed:meshHeading | pubmed-meshheading:7700889-... | lld:pubmed |
| pubmed-article:7700889 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7700889 | pubmed:articleTitle | Effects of cyclosporine on ovarian function in sham-operated and pituitary-grafted young female rats. | lld:pubmed |
| pubmed-article:7700889 | pubmed:affiliation | Departamento de Bioquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain. | lld:pubmed |
| pubmed-article:7700889 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7700889 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
