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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1995-4-28
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pubmed:abstractText |
Effects of cyclosporine (CyA) on ovarian function and the possible role of prolactin in mediating these effects were examined in young female rats. The animals were sham-operated or rendered hyperprolactinemic by transplanting pituitary glands under the renal capsule. Cyclosporine prevented the increase in plasma prolactin levels in grafted rats. However, in sham-operated animals plasma prolactin levels were increased after 8 days of CyA treatment. Plasma levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were reduced 8 days after pituitary grafting and increased by CyA at both Day 2 and Day 8 of treatment. The content of LHRH in the hypothalamus was not affected on Day 2 but was reduced on Day 8 after grafting on CyA therapy. Plasma estradiol levels were increased by CyA in sham-operated rats on Day 2 and 8 of treatment, and in pituitary-grafted rats on Day 8 of therapy. In sham-operated rats, ovarian estradiol content was reduced after 2 and after 8 days of CyA administration. In pituitary-grafted rats, the ovarian estradiol content was suppressed after 8 days, and CyA treatment prevented this effect. Ovarian estradiol release in vitro under basal conditions was greater in ovaries derived from 38-day-old than in those from 32-day-old animals. The ovarian estradiol response to human chorionic gonadotropin (hCG) in vitro was increased 2 days after pituitary transplantation. Administration of CyA for 8 days increased basal and hCG-stimulated estradiol release in both sham-operated and pituitary-grafted animals. The present findings suggest that CyA can alter ovarian function by acting directly at the gonadal level. However, a hypothalamic-hypophyseal site of action cannot be ruled out.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Follicle Stimulating Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Luteinizing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Prolactin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0037-9727
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
208
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
397-403
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pubmed:dateRevised |
2007-11-2
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pubmed:meshHeading |
pubmed-meshheading:7700889-Animals,
pubmed-meshheading:7700889-Cyclosporine,
pubmed-meshheading:7700889-Estradiol,
pubmed-meshheading:7700889-Female,
pubmed-meshheading:7700889-Follicle Stimulating Hormone,
pubmed-meshheading:7700889-Luteinizing Hormone,
pubmed-meshheading:7700889-Male,
pubmed-meshheading:7700889-Ovary,
pubmed-meshheading:7700889-Pituitary Gland, Anterior,
pubmed-meshheading:7700889-Prolactin,
pubmed-meshheading:7700889-Radioimmunoassay,
pubmed-meshheading:7700889-Rats,
pubmed-meshheading:7700889-Rats, Wistar,
pubmed-meshheading:7700889-Reference Values,
pubmed-meshheading:7700889-Time Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Effects of cyclosporine on ovarian function in sham-operated and pituitary-grafted young female rats.
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pubmed:affiliation |
Departamento de Bioquímica, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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