Linked Life Data

7699373

Source:http://linkedlifedata.com/resource/pubmed/id/7699373

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-5-3
pubmed:abstractText
The authors studied the use of epidural anesthesia prolonged to 48 hours of epidural analgesia in 120 total hip arthroplasty patients in a case-control fashion. One half of the patients received prolonged epidural anesthesia, while the other matched half received general endotracheal anesthesia. Venograms were obtained after surgery and graded in blind fashion by a single radiologist. The overall incidence of deep venous thrombosis in the epidural versus general anesthetic groups was 23 (14 of 60 patients) versus 40% (24 of 60) (P < .05). There was an identical incidence--8.3% (5 of 60 patients)--of proximal thrombosis in the two groups, and all of the difference in the overall rates of thrombosis occurred in the calf. Fifteen percent (9 of 60 patients) of the epidural patients and 31.6% (19 of 60) of the general anesthetic patients demonstrated this finding (P < .05). Of the 10 proximal clots, 8 (80%) were found in the operative leg, while only 29 (59.2%) of the 49 calf clots were found in the operative leg. Prolonged epidural anesthesia significantly decreases the incidence of deep venous thrombosis after total hip arthroplasty, with its most apparent benefit on calf vein thrombosis secondary to its hyperkinetic effect on lower limb blood flow. The observation that it has no demonstrable effect on the prevention of proximal thrombosis and our finding that the majority of proximal clots are in the operative leg suggest that thrombi in the thigh may be the result of a different primary pathogenic mechanism that is more related to endothelial injury than to changes in viscosity or blood flow.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0883-5403
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
611-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Deep venous thrombosis following total hip arthroplasty. Effects of prolonged postoperative epidural anesthesia.
pubmed:affiliation
Department of Orthopaedics, University of Rochester School of Medicine, New York.
pubmed:publicationType
Journal Article, Clinical Trial, Controlled Clinical Trial